JSM 2004 - Toronto

Abstract #300265

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Activity Number: 141
Type: Invited
Date/Time: Monday, August 9, 2004 : 2:00 PM to 3:50 PM
Sponsor: General Methodology
Abstract - #300265
Title: Stochastic Analysis of Single Molecule Experiments
Author(s): Samuel Kou*+ and Sunney Xie and Jun S. Liu
Companies: Harvard University and Harvard University and Harvard University
Address: Science Center, 1 Oxford St., Cambridge, MA, 02138,
Keywords: likelihood ; Brownian diffusion ; continuous-time Markov chain ; Cox process ; Ornstein-Uhlenbeck process
Abstract:

Recent technological advances allow scientists for the first time to follow a biochemical process on a single molecule basis, which raises many challenging data-analysis problems. This paper provides the first likelihood-based analysis of the single-molecule fluorescence lifetime experiment, in which the conformational dynamics of a single DNA hairpin molecule is of interest. The conformational change is not directly observable and has to be inferred from changes in photon emissions from a dye attached to the DNA hairpin molecule. In addition to the hidden structure, the presence of molecular Brownian diffusion further complicates the matter. We show that the data augmentation technique can be utilized to handle both the Brownian diffusion and the issue of model discrimination. Our results increase the estimating resolution by several folds. The success of this analysis indicates there is an urgent need to bring modern statistical techniques to the analysis of data produced by modern technologies.

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Revised March 2004