JSM 2004 - Toronto

Abstract #300231

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Activity Number: 207
Type: Invited
Date/Time: Tuesday, August 10, 2004 : 10:30 AM to 12:20 PM
Sponsor: Section on Statistics in Epidemiology
Abstract - #300231
Title: Design and Efficiency Issues in Two-phase Studies
Author(s): Jerald F. Lawless*+ and Donald L. McLeish and Yang Zhao
Companies: University of Waterloo and University of Waterloo and University of Waterloo
Address: Dept. of Statistics and Act. Sci., Waterloo, ON, N2L 3G1, Canada
Keywords: incomplete data ; response selection ; restricted sampling
Abstract:

Two-phase epidemiological studies in which the objective is to relate certain response variables to covariates are often conducted. At phase 1, variables that are easily or inexpensively measured are observed on a group of individuals. At phase 2 a random subset of these individuals is selected, and more expensive measurements taken. When the probability an individual is chosen for phase 2 depends on their phase 1 measurements, the combined sampling procedure is often outcome-dependent. The efficiency and cost of such studies depends on the sizes of the phase 1 and 2 samples, the phase 2 inclusion probabilities, and the true relationships between variables in the study. This talk examines these issues and the choice of good designs in "expensive covariate" and "expensive response" settings.

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Revised March 2004