JSM 2004 - Toronto

Abstract #300161

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Activity Number: 393
Type: Invited
Date/Time: Thursday, August 12, 2004 : 8:30 AM to 10:20 AM
Sponsor: ENAR
Abstract - #300161
Title: Model Selection for Dynamic Survival Analysis
Author(s): Ian W. McKeague*+
Companies: Florida State University
Address: Department of Statistics, Tallahassee, FL, 32306-4330,
Keywords: hazard function regression ; censored data ; additive risk model ; covariate selection ; nonproportional hazards
Abstract:

Model selection methods are well developed in parametric settings, and in recent years they have been extended to wide classes of nonparametric models. For dynamic survival models which involve complex time-dependent covariates and coefficients, however, generally applicable and fully validated procedures are not yet available. This talk discusses a new approach that applies to a flexible class of nonproportional hazard function regression models in which the influence of the covariates splits into the sum of a parametric part and a time-dependent nonparametric part. The approach allows covariate selection for the parametric part by adjusting for the implicit fitting of the nonparametric part. Asymptotic consistency is established, leading to asymptotically normal estimators of both parametric and nonparametric parts of the model in the presence of covariate selection. The approach is illustrated using real and simulated data.


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