JSM 2004 - Toronto

Abstract #302152

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Activity Number: 339
Type: Contributed
Date/Time: Wednesday, August 11, 2004 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section
Abstract - #302152
Title: On the Adaptiveness of a Simple Bayesian Model for Treatment Assignments in Clinical Trials
Author(s): Abdul J. Sankoh*+
Companies: Aventis Pharmaceuticals
Address: P O Box 6890, Bridgewater, NJ, 08807,
Keywords: adaptiveness ; Bayesian ; clinical trials ; treatment assignment
Abstract:

The need to design cost-effective and ethically sensitive clinical trials has re-energized the drive for more flexible clinical trial designs and statistical methods. There is a renewed research focus on the development of statistically and ethically efficient adaptive clinical trial methodologies by scientists both at the industry and regulatory agencies. This presentation discusses the properties of a simple Bayesian adaptive treatment assignment tool in clinical trails to minimize the number of subjects' exposed to the inferior treatment arm. The close resemblance of this simple Bayesian adaptive model to some popular frequentist models is examined.

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Revised March 2004