JSM 2004 Online Program

Abstract #302133

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Activity Number:	221
Type:	Contributed
Date/Time:	Tuesday, August 10, 2004 : 10:30 AM to 12:20 PM
Sponsor:	Biopharmaceutical Section
Abstract - #302133
Title:	A New Approach for Simple One-compartment PK Models
Author(s):	Donghui Zhang*+
Companies:	Merck & Co., Inc.
Address:	PO Box 2000, RY33-300, Rahway, NJ, 07065,
Keywords:	PK model ; mixed effects model
Abstract:	Pharmacokinetic (PK) models, usually nonlinear, characterize the process of drug absorption, distribution, elimination using the inferred form of plasma concentration as a function of time. A particular mixed effect model approach has been developed for the simple one-compartment model. Unlike the current methods, we do not restrict the distribution of the random effects to be log-normal, and we do not use the usual linear approximation, thus removing the source of inconsistency when estimating population parameters. This new approach especially suits the routine population PK data where the number of observations from each indiviudal is small, while the total number of individuals can be sufficiently large.

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