JSM 2004 - Toronto

Abstract #301991

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Activity Number: 223
Type: Contributed
Date/Time: Tuesday, August 10, 2004 : 10:30 AM to 12:20 PM
Sponsor: Biometrics Section
Abstract - #301991
Title: Improved Changepoint Methods for the Analysis of Array-based DNA Copy Number Data
Author(s): Adam B. Olshen*+ and E. S. Venkatraman
Companies: Memorial Sloan-Kettering Cancer Center and Memorial Sloan-Kettering Cancer Center
Address: 307 East 63rd St., New York, NY, 10021,
Keywords: changepoint ; binary segmentation ; CBS ; DNA copy number ; array CGH ; ROMA
Abstract:

We have previously presented circular binary segmentation (CBS), a method for analyzing DNA copy number data. We now present improvements to it. These include a second round of segmentation that splits the data relative to a reduced set of means. Also, we present a modification if the data are binary.

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