JSM 2004 - Toronto

Abstract #301923

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Activity Number: 435
Type: Contributed
Date/Time: Thursday, August 12, 2004 : 10:30 AM to 12:20 PM
Sponsor: SSC
Abstract - #301923
Title: A Robust Transmission/Disequilibrium Test for Incomplete Family Genotypes
Author(s): Gulhan Alpargu*+ and Paola Sebastiani and Maria M Abad and Marco Ramoni
Companies: University of Massachusetts and Boston University and University of Granada and Harvard Medical School
Address: Dept. of Mathematics and Statistics, Amherst, MA, 01003,
Keywords: TDT ; SNP ; missing genotype ; robust inference
Abstract:

Several solutions have been proposed to extend the Transmission Disequilibrium Test (TDT) to deal with missing parental genotype. All these solutions remedy the problem of missing parental genotype, while offsprings with missing genotypes are typically not taken into account. However, the treatment of such reconstructed parental genotypes can introduce bias if the underlying missing data mechanism is informative. We propose an extension to the TDT, called robust TDT (rTDT), which can cope with incomplete genotypes on both parents and children. RTDT computes minimum and maximum values of TDT that are consistent with all possible completions of the missing data. RTDT is applied to a database of markers of susceptibility to Crohn Disease, and shows that only two of the 11 markers originally associated to phenotype do not depend on assumptions about the missing data mechanism.

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