JSM 2004 - Toronto

Abstract #301918

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Activity Number: 43
Type: Topic Contributed
Date/Time: Sunday, August 8, 2004 : 4:00 PM to 5:50 PM
Sponsor: Biometrics Section
Abstract - #301918
Title: Fine Mapping of QTL in Complex Pedigrees
Author(s): Natascha Vukasinovic*+
Companies: Monsanto Animal AG Genomics
Address: 700 Chesterfield Pkwy. W, Chesterfield, MO, 63017,
Keywords: linkage analysis ; linkage disequilibrium ; quantitative trait loci ; pedigree
Abstract:

To date, two general approaches have been used to map quantitative trait loci (QTL) in human and animal populations: linkage analysis (LA) and linkage disequilibrium (LD) approach. The LA approach utilizes information on recombination events between genetic markers in a pedigree. With the LA approach, the QTL position is estimated with a large error, caused by a small number of recombinations in the genotyped pedigree that commonly comprises only two to three generations. The LD approach utilizes information on historical recombinations, thus providing more precise estimates of the QTL position. However, the LD approach can produce false positive results if LD results from causes other than the mutation at the QTL. Recently, methods that combine advantages of both LA and LD approaches have been proposed. We apply the LA/LD approach in complex multigenerational pedigrees and investigate its efficiency and power for QTL mapping under different scenarios regarding pedigree structure, degree of linkage disequilibrium, and availability of marker information.

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