JSM 2004 - Toronto

Abstract #301740

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Activity Number: 310
Type: Contributed
Date/Time: Wednesday, August 11, 2004 : 8:30 AM to 10:20 AM
Sponsor: Biometrics Section
Abstract - #301740
Title: On Genetic Linkage/association Analysis with Incomplete Parental Information
Author(s): Jing Han*+ and Yongzhao Shao
Companies: New York University and New York University
Address: 650 1st Ave., 5th floor, New York, NY, 10016,
Keywords: genetic linkage analysis ; missing parental genotypes ; marker locus ; linkage disequilibrium ; genetic association test ; power analysis
Abstract:

We study the problem of detecting linkage/association for family-based genetic data. The proposed test is applicable without knowledge of disease penetrance, mating types, the amount of linkage disequilibrium, etc. Simulation shows that it works well even when parental marker genotype information is incomplete.


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Revised March 2004