JSM 2004 - Toronto

Abstract #301706

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Activity Number: 17
Type: Topic Contributed
Date/Time: Sunday, August 8, 2004 : 2:00 PM to 3:50 PM
Sponsor: Section on Statistics in Epidemiology
Abstract - #301706
Title: Leukemia Mortality after Fractionated Moderate-dose-rate Ionizing Radiation in the Canadian Fluoroscopy Cohort and a Comparison with Leukemia Mortality among the A-bomb Survivors
Author(s): Lydia Zablotska*+
Companies: Columbia University
Address: 722 West 168th St., New York, NY, 10032,
Keywords: leukemia ; mortality ; chronic lymphocytic leukemia ; fluoroscopy ; atomic bomb survivors
Abstract:

Canadian fluoroscopy cohort was used to analyze mortality experience from leukemia due to exposure to fractionated moderate-dose-rate ionizing radiation between 1950 and 1987. A substantial fraction (39%) of subjects received multiple chest x-ray fluoroscopies during the course of pneumothorax for treatment of tuberculosis. Individual bone marrow doses were estimated from combination of the number of fluoroscopies, interviews with physicians who conducted pneumothorax, and data from an experimental human phantom study of organ dose per unit of surface exposure produced by contemporary fluoroscopes. Poisson regression analyses were used to estimate excess relative rates per gray (ERR per Gy) and the associated measures of uncertainty. Cumulative person-year experience was cross-classified by sex, age risk, calendar year at risk, and province. There were 148 deaths from leukemia among 66,464 subjects (13 were chronic lymphocytic leukemia (CLL)). Categorical analyses showed a pattern of increasing risks with increasing dose. Linear dose-response analyses showed increased risks for all leukemia (ERR=0.77) and leukemia excluding CLL (ERR=1.2).

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