JSM 2004 - Toronto

Abstract #301705

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Activity Number: 368
Type: Topic Contributed
Date/Time: Wednesday, August 11, 2004 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #301705
Title: Handling Missing Radiographic Data in Rheumatoid Arthritis Clinical Trials
Author(s): Kimberly L. DeWoody*+
Companies: Centocor, Inc.
Address: 200 Great Valley Pkwy., Malvern, PA, 19355,
Keywords: missing data ; radiographic data ; rheumatoid arthritis
Abstract:

In rheumatoid arthritis clinical trials, radiographs of the hands and feet are taken to assess structural damage. Using a standardized scoring system, independent and blinded readers score each of the joints for erosions and joint space narrowing. Missing radiographic data can occur on a joint-level for reasons such as inadequate image quality or poor patient positioning. Missing data can also occur on a patient-level due to the patient missing a visit for various reasons, including patient withdrawal from the study or being lost to follow-up. Approaches to handling the missing radiographic data will be discussed.

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Revised March 2004