JSM 2004 - Toronto

Abstract #301506

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Activity Number: 114
Type: Contributed
Date/Time: Monday, August 9, 2004 : 10:30 AM to 12:20 PM
Sponsor: ENAR
Abstract - #301506
Title: Analytic Strategies for Pre-Processing in Proteomics Experiments
Author(s): Laura L. Johnson*+
Companies: Centers for Disease Control and Prevention
Address: NCI/CPSB, 6116 Executive Blvd., Bethesda, MD, 20892-8314,
Keywords: proteomics ; mass spectrometry ; SELDI-TOF ; measurement error
Abstract:

Using Surface Enhanced Laser Desorption/Ionization-Time of Flight (SELDI-TOF) mass spectrometry (MS) data as an example, we discuss current statistical methods concerning how to align peaks and how to calibrate mass/charge measurements across multiple samples. Output from a specimen yields a series of (x,y) points with x the protein mass divided by the number of charges introduced by ionization (M/Z) and y the protein intensity of the M/Z value in the specimen. Two measurement error issues, measurement error in the absolute values of the intensity for any given M/Z point and drift experiment to experiment by the M/Z axis (x-axis) need to be addressed before analysis can begin. These methods apply to data from other proteomic platforms and are vital when constructing and evaluating disease classifiers.

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