JSM 2004 - Toronto

Abstract #301215

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Activity Number: 102
Type: Topic Contributed
Date/Time: Monday, August 9, 2004 : 10:30 AM to 12:20 PM
Sponsor: ENAR
Abstract - #301215
Title: On the Study of Hypothetical Health Constructs
Author(s): Karen Bandeen-Roche*+
Companies: Johns Hopkins University
Address: Dept. of Biostatistics, Baltimore, MD, 21205,
Keywords: latent variable ; measurement ; pseudo-values ; validity ; aging ; Monte Carlo
Abstract:

In a number of fields, there exist important adverse health states that are viewed as widely recognizable by physicians but lack consensus conceptualization or modes of measurement. Two examples are "frailty" in geriatrics and "abnormal personality" in psychology. Advancing related research requires a combination of testing theories on the nature of constructs at issue and delineation of the operational characteristics of various proposals for their surrogate measurement. This talk discusses the formulation of such theories within latent variable models, proposes a strategy for evaluating internal and external validity, and applies the methodology to the frailty measurement problem. The validity evaluation strategy relies on randomized generation of underlying health state values a posteriori, increasingly termed "pseudo-values," and subsequent inference utilizing those values while accounting for the model-fitting process. The work ultimately aims to equip researchers with surrogate measures of hypothetical health constructs that more precisely operationalize clinical impression than do the ad hoc surrogates that predominate in extant research.

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