JSM 2004 - Toronto

Abstract #301164

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Activity Number: 438
Type: Contributed
Date/Time: Thursday, August 12, 2004 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section
Abstract - #301164
Title: Comparison of Variances of Response Data in a Cross-over Study
Author(s): Jiannong Wang*+
Companies: Novartis Pharmaceuticals
Address: Biometric - US CD&MA, East Hanover, NJ, 07936-1080,
Keywords: cross-over study ; variance comparison ; correlated data
Abstract:

Usually the response data from different periods in a cross-over study will be considered to be correlated. Since the assumption of independence of two samples is not satisfied, the traditional F-test techniques will not be applicable when the variances of numeric responses need to be compared under certain circumstances. Some research results on how the data can be analyzed will be presented. First, distribution of the (correlated) F-statistics will be investigated. Some tables of the percentile values will be provided. Then bootstrapping methodology will be applied on same examples. The results from bootstrapping methods will be checked against the tables of the percentile values.

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