JSM 2004 Online Program

Abstract #301088

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Activity Number:	164
Type:	Contributed
Date/Time:	Monday, August 9, 2004 : 2:00 PM to 3:50 PM
Sponsor:	Biometrics Section
Abstract - #301088
Title:	Performance of Floating Absolute Risks
Author(s):	Patrick G. Arbogast*+
Companies:	Vanderbilt University
Address:	Dept. of Biostatistics, Nashville, TN, 37232-2158,
Keywords:	confidence intervals ; hazard ratio ; proportional hazards regression ; relative risk ; survival analysis
Abstract:	A recent investigation of hormone-replacement therapy and breast cancer risk used a method called "floating absolute risks" (FARs) to compute confidence intervals for relative hazards. This method has been reported in other medical studies and has received controversy as to its appropriateness. However, there has been no direct comparison of the FAR method to the standard approach for computing confidence intervals from proportional hazards regression. I report simulation results comparing these two methods and demonstrate that the FAR method can substantially underestimate the width of confidence intervals for relative hazards.

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