JSM 2004 - Toronto

Abstract #300380

This is the preliminary program for the 2004 Joint Statistical Meetings in Toronto, Canada. Currently included in this program is the "technical" program, schedule of invited, topic contributed, regular contributed and poster sessions; Continuing Education courses (August 7-10, 2004); and Committee and Business Meetings. This on-line program will be updated frequently to reflect the most current revisions.

To View the Program:
You may choose to view all activities of the program or just parts of it at any one time. All activities are arranged by date and time.

The views expressed here are those of the individual authors
and not necessarily those of the ASA or its board, officers, or staff.

Back to main JSM 2004 Program page
Activity Number: 291
Type: Topic Contributed
Date/Time: Wednesday, August 11, 2004 : 8:30 AM to 10:20 AM
Sponsor: Biopharmaceutical Section
Abstract - #300380
Title: Post-randomization Change in Cancer Treatment: Statistical Analysis of Treatment Effect (1)
Author(s): Peiling Yang*+ and Yong-Cheng Wang
Companies: U.S. Food and Drug Administration and U.S. Food and Drug Administration
Address: 1451 Rockville Pike, HFD-710, Rockville, MD, 20852,
Keywords: noncompliance ; survival analysis
Abstract:

In randomized studies of cancer treatments, oncologists may change treatments prior to assessing the primary endpoint, thus potentially obscuring treatment effects from study treatments. Reasons for change in therapy include drug toxicity, tumor progression, and changes in surrogate markers. This presentation will focus on estimating treatment effect when patients switch treatments from the assigned to the alternative after randomization in oncology clinical trials. We will explore the prognostic factors that may be correlated with treatment noncompliance and discuss issues in statistical analysis from the regulatory perspective.

  • The address information is for the authors that have a + after their name.
  • Authors who are presenting talks have a * after their name.

Back to the full JSM 2004 program

JSM 2004 For information, contact jsm@amstat.org or phone (888) 231-3473. If you have questions about the Continuing Education program, please contact the Education Department.
Revised March 2004