JSM 2004 - Toronto

Abstract #300219

This is the preliminary program for the 2004 Joint Statistical Meetings in Toronto, Canada. Currently included in this program is the "technical" program, schedule of invited, topic contributed, regular contributed and poster sessions; Continuing Education courses (August 7-10, 2004); and Committee and Business Meetings. This on-line program will be updated frequently to reflect the most current revisions.

To View the Program:
You may choose to view all activities of the program or just parts of it at any one time. All activities are arranged by date and time.

The views expressed here are those of the individual authors
and not necessarily those of the ASA or its board, officers, or staff.

Back to main JSM 2004 Program page
Activity Number: 417
Type: Invited
Date/Time: Thursday, August 12, 2004 : 10:30 AM to 12:20 PM
Sponsor: Biometrics Section
Abstract - #300219
Title: Inference on Cell Proliferation from Clonal Data
Author(s): Ollivier Hyrien*+
Companies: University of Rochester Medical Center
Address: Dept. of Biostatistics and Computational Biology, Rochester, NY, 14642,
Keywords: branching process ; cell proliferation ; simulation-based inference
Abstract:

We present a method for statistical inference on the proliferation of cell clones composed of two (or more) distinct types of cells. A stochastic model designed to analyze experimental data on the development of cell clones is presented. The proposed model is an extension of the traditional multitype Bellman-Harris branching process allowing for nonidentical time-to-transformation distributions defined for different cell types. A simulation-based procedure has been developed for parametric inference from experimental data on cell clones under the proposed model. The model and associated methods of parametric inference are applied to the analysis of proliferation and differentiation of cultured O-2A progenitor cells that play a key role in the development of the central nervous system.

  • The address information is for the authors that have a + after their name.
  • Authors who are presenting talks have a * after their name.

Back to the full JSM 2004 program

JSM 2004 For information, contact jsm@amstat.org or phone (888) 231-3473. If you have questions about the Continuing Education program, please contact the Education Department.
Revised March 2004