JSM 2004 - Toronto

Abstract #300144

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Activity Number: 169
Type: Invited
Date/Time: Tuesday, August 10, 2004 : 8:30 AM to 10:20 AM
Sponsor: WNAR
Abstract - #300144
Title: Regression Methods for Multiple-sequence Recurrent-event Data
Author(s): Douglas E. Schaubel*+ and Jianwen Cai
Companies: University of Michigan and University of North Carolina, Chapel Hill
Address: Department of Biostatistics, 1420 Washington Hts, Ann Arbor, MI, 48109-2029,
Keywords: missing data ; multiple imputation ; proportional means model ; weighted estimating equations
Abstract:

Censored recurrent event data frequently arise in biomedical studies. Often, the events are not homogenous, and may be categorized. An analysis which incorporates event categorization may be much more informative than one which aggregates across event categories, particularly when estimating covariate effects. The resulting data structure may be viewed as multiple recurrent event sequences. We propose semiparametric regression methods for analyzing such multiple-sequence recurrent event data. We also consider the setting where event times are known, but the event category may be missing. Parameter estimators are shown to be consistent and asymptotically normal, while finite sample properties are examined through simulation. The proposed methods are applied to an end-stage renal disease dataset obtained from a national organ failure registry.


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Revised March 2004