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Activity Number:
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395
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Type:
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Invited
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Date/Time:
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Thursday, August 12, 2004 : 8:30 AM to 10:20 AM
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Sponsor:
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International Indian Statistical Association
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| Abstract - #300091 |
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Title:
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On the Use of Biomarkers for Carcinogen Risk Assessment
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Author(s):
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Louise M. Ryan*+ and Sally W. Thurston and Wenzheng Huang
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Companies:
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Harvard School of Public Health and University of Rochester and Millennium Operations
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Address:
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Dept Biostatistics, Boston, MA, 02115,
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Keywords:
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surrogate marker ; benchmark dose ; dose response
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Abstract:
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There is growing interest in the use of biomarker data in environmental health research, and in particular for helping to quantify dose response relationships. We will discuss some of the challenging statistical issues that arise in this context. We specify a modeling framework that links environmental exposure, biomarkers, and outcome, and discuss in conceptual terms how such a formulation could be used to inform dose response modeling for the purpose of quantitative risk assessment. We analyze data from a case-control study designed to elucidate the mechanisms of smoking-induced lung cancer. Because of sample size limitations, we use a likelihood-based analysis which subsumes both cohort and case-control designs as special cases. Our analysis allows us to (1) investigate the extent to which the markers explain the pathway from exposure to outcome; (2) quantify the degree to which biomarker data can improve on predicting outcome over and above exposure; and (3) estimate the association among multiple markers.
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