JSM 2004 Online Program

Abstract #300066

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Activity Number:	144
Type:	Invited
Date/Time:	Monday, August 9, 2004 : 2:00 PM to 3:50 PM
Sponsor:	ENAR
Abstract - #300066
Title:	The Additive Genetic Gamma Frailty Models: Alternative Estimation and Inferences
Author(s):	Hongzhe Li*+
Companies:	University of California, Davis
Address:	Rowe Progam in Human Genetics, Davis, CA, 95616,
Keywords:	additive gamma frailty model ; genetic linkage analysis ; age of onset ; pseudo-likelihood ; ascertainment
Abstract:	The additive genetic gamma frailty has been proposed for genetic linkage analysis to take into account variable age of onset and covariates information. The retrospective likelihood approach is often used for parameter estimation and for the test of genetic linkage. I will discuss some alternative methods for parameter estimation and hypothesis-testing, including a pseudo-likelihood approach and an ascertaint-adjusted likelihood approach for estimating the model parameters. Some thoretical and simulations results will be presented.

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