JSM 2004 - Toronto

Abstract #300046

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Activity Number: 417
Type: Invited
Date/Time: Thursday, August 12, 2004 : 10:30 AM to 12:20 PM
Sponsor: Biometrics Section
Abstract - #300046
Title: Random Effects Models for the Transmission of Dynamic Mutations
Author(s): Richard Huggins*+ and Minh Bui and Guoqi Qian and Danuta Loesch
Companies: La Trobe University and La Trobe University and La Trobe University and La Trobe University
Address: Dept. of Statistical Science, Bundoora, International, 3086, Australia
Keywords: MCMC ; model selection ; hierarchical Bayes
Abstract:

Hierarchical models for the transmission of the CGG repeat sequence associated with the fragile X dynamic mutation in the FMR1 gene are developed. The models incorporate both genetic and family effects on the expansion rate of the sequence as random effects. The emphasis is on comparing models for the distribution of the residuals.

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Revised March 2004