Abstract #302161

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JSM 2003 Abstract #302161
Activity Number: 133
Type: Contributed
Date/Time: Monday, August 4, 2003 : 12:00 PM to 1:50 PM
Sponsor: Biometrics Section
Abstract - #302161
Title: Early Classification of Pregnancy Outcome Using Hormone Levels in IVF Patients
Author(s): Monnie McGee*+
Companies: Southern Methodist University
Address: 3225 Daniel Ave.-144 Heroy Bldg., Dallas, TX, 75275-0332,
Keywords: classification ; biostatistics ; IVF patients ; missing data ; irregularly spaced time intervals
Abstract:

We have been presented with hormone levels from 63 IVF patients who have been classified according to the following outcomes: biochemical pregnancy, miscarriage, or live birth. We also have information on the number of fetal heartbeats and the number of live births per subject. The hormones in question are two forms of hCG: B152 and B109. They are measured at irregularly spaced time points throughout each subject's first trimester. In the event of a biochemical pregnancy or miscarriage, data collection stops, as the hormone levels are no longer necessary. We wish to use these variables to classify future subjects according to outcome before the event is demonstrable by other means, such as ultrasound. We will compare the performance of several methods of classifcation, including linear discriminant analysis, logistic regression, separating hyperplanes, and classifcation trees. We also hope to present modifications of these methods which will include information from multiple irregularly spaced time points and account for the lack of data for some subjects.

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