Abstract #302063

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JSM 2003 Abstract #302063
Activity Number: 133
Type: Contributed
Date/Time: Monday, August 4, 2003 : 12:00 PM to 1:50 PM
Sponsor: Biometrics Section
Abstract - #302063
Title: The Application of the Runs Test on Sequential Single-Point Lod Score to Determine Areas of Linkage
Author(s): Derek M. Blankenship*+ and Barbara R. Neas
Companies: University of Oklahoma Health Science Center and University of Oklahoma Heath Sciences Center
Address: 936 N.E. 4th St., Moore, OK, 73160-5334,
Keywords: genetics ; linkage ; runs test ; GAW11 ; lod score
Abstract:

The purpose of this project is to evaluate the use of the runs test to detect nonrandom patterns that would be expected with sequential single-point lod scores and a linked trait. The simulated dataset were from the 11th Genetic Analysis Workshop. The simulation was developed to mimic the markers of a complex disease with two separate genetic components, and as well as various family sampling methods. Each of the 25 replicates contains four studies with one hundred nuclear families each. There are 50 equidistant markers on each of the six chromosomes and no missing data. Two different runs tests are applied systematically to the lod scores calculated by SAGE 3.1, one being the runs up and down and the other being above and below zero lod scores. Presented will be the ability of these runs tests to detect regions of a chromosome that are linked to a disease while not necessarily having significant lod scores using different sampling methods. This would theoretically give researchers a method of determining regions of interest with smaller sample sizes.

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