Abstract #302030

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JSM 2003 Abstract #302030
Activity Number: 253
Type: Topic Contributed
Date/Time: Tuesday, August 5, 2003 : 12:00 PM to 1:50 PM
Sponsor: Biometrics Section
Abstract - #302030
Title: A Spatial Analysis of Brain Imaging Data
Author(s): Jeff S. Spence*+ and Patrick S. Carmack and William R. Schucany and Richard F. Gunst and Wayne A. Woodward
Companies: Southern Methodist University and Southern Methodist University and Southern Methodist University and Southern Methodist University and Southern Methodist University
Address: 10030 Lanshire Dr., Dallas, TX, 75238-3435,
Keywords: SPECT ; spatial ; Gulf War ; Talairach ; voxel
Abstract:

Single-photon emission computed tomography (SPECT) imaging, a technique use for clinical studies of the brain, involves the detection of photons emitted from a radionuclide source, followed by the amplification of an electrical signal measured as an intensity. Low resolution and high variability lead to a low signal to noise ratio, making regional changes within the brain difficult to detect. We are investigating spatial statistical methods to identify changes in signal intensity and increase the sensitivity of tests. Rather than a voxel by voxel analysis, we isolate structures of interest using an appropriate coordinate transformation based on the Talairach atlas. Since the correlation of signal intensities within structures may extend several millimeters in length, modeling SPECT data using spatial theory allows us to take advantage of the correlation and compare volume averages appropriately. Initial investigations of this application of spatial techniques are demonstrated using data from 39 subjects directly or indirectly involved in the Gulf War, 22 who were identified by other procedures as having Gulf War Syndrome.

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