Abstract #301957

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JSM 2003 Abstract #301957
Activity Number: 95
Type: Contributed
Date/Time: Monday, August 4, 2003 : 8:30 AM to 10:20 AM
Sponsor: Biometrics Section
Abstract - #301957
Title: Generalized Tests for Replicated Microarray Data
Author(s): Mei-Ling Ting Lee*+ and Robert J. Gray
Companies: Harvard University and Dana Farber Cancer Institute
Address: Channing Laboratory, HMS/BWH, Boston, MA, 02115-5804,
Keywords: rank tests ; replications ; microarray data
Abstract:

Gene expression data from microarray experiments with replications have been studied based on several parametric models. Robust nonparametric statistical methods are needed for analyzing replicated microarray data. Moreover, due to the cost of microarray experiments, sample sizes are often small. Hence, our inference will be based on permutation tests. We generalize (1) the rank sum test for comparing replicated measurements from treatments applied to two sets of independent samples; and (2) the Wilcoxon signed rank test for comparing replicated measurements obtained from treatments applied to matched samples. We develop inferences for analyzing replicated gene expression data.

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