Abstract #301871

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JSM 2003 Abstract #301871
Activity Number: 28
Type: Contributed
Date/Time: Sunday, August 3, 2003 : 2:00 PM to 3:50 PM
Sponsor: Biometrics Section
Abstract - #301871
Title: High-Resolution Joint Linkage Disequilibrium and Linkage Mapping of Quantitative Trait Loci Based on Sibship Data
Author(s): Ruzong Fan*+
Companies: Texas A&M University
Address: Dept. of Statistics, College Station, TX, 77843,
Keywords: QTL ; linkage analysis ; LD mapping ; IBD ; variance component models
Abstract:

Variance component models are proposed for high-resolution joint linkage disequilibrium (LD) and linkage mapping of quantitative trait loci (QTL) based on sibship data, which include population data if one treats an independent individual as one sibship. One motivation is to build valid models for late-onset complex disease gene mapping when parental data are not available. The models simultaneously take care of LD information and linkage information. The LD coefficients are contained in mean coefficients of sibship data which include population data. The linkage information is contained in variance-covariance matrix of trait values of sibships with at least two siblings. We derive formulas to calculate the probability of sharing 2 trait allele identical by descent (IBD) of sib pairs for interval mapping of QTL, which is the coefficient of dominant variance of the trait covariance of sib pairs on major QTL. The merits of the method are explored by numerical calculation, power and sample size comparison.

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