Abstract #301721

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JSM 2003 Abstract #301721
Activity Number: 458
Type: Invited
Date/Time: Thursday, August 7, 2003 : 10:30 AM to 12:20 PM
Sponsor: Biometrics Section
Abstract - #301721
Title: Using Racially Admixed Groups to Understand Disease Susceptibility
Author(s): Alice S. Whittemore*+ and Geraldine Clarke
Companies: Stanford University and Stanford University
Address: School of Medicine, Stanford, CA, 94305,
Keywords: ancestry index ; haplotypes ; ancestral test ; admixture ; genetic polymorphisms
Abstract:

Epidemiologists have found strong differences in disease risk across populations with different racial/ethnic backgrounds. However, the reasons for these differences have been elusive: are they due to differences in genetic factors; differences in social, cultural or lifestyle factors; or both? The answer is complicated by the admixed genetic backgrounds of U.S. racial/ethnic groups: the genes of most U.S. whites, African Americans, Asian Americans, and Hispanics have been inherited from more than one of the five main world races. Recent technical advances in genetics have made it feasible to estimate admixture proportions for an individual, using his/her alleles at selected DNA markers. This talk will describe methods for estimating these individual admixture proportions. Such estimation raises the question, How do the admixture estimates correlate with disease risk? Strong correlation may provide clues to genes responsible for the disease. In addition, stratification on ancestry may allow more accurate evaluation of associations between disease risk and social, cultural, and lifestyle factors in genetically heterogeneous populations.

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