Abstract #301707

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JSM 2003 Abstract #301707
Activity Number: 29
Type: Contributed
Date/Time: Sunday, August 3, 2003 : 2:00 PM to 3:50 PM
Sponsor: Biometrics Section
Abstract - #301707
Title: Contrasts in Nonorthogonal Mixed Models
Author(s): Bob E. Kempson*+
Companies: GlaxoSmithKline R&D
Address: Park Dr., Ware, , SG12 0DP, United Kingdom
Keywords: mixed models ; nonorthogonal ; experimental designs
Abstract:

Block designs are commonly used throughout scientific research and are useful when it is required to investigate treatment differences in the presence of systematic variation between experimental units arranged in blocks. If blocks are of unequal size, the design and analysis become more complex, and the allocation of treatments at the design stage merits close investigation. The paper uses two programs written in SAS IML, which permit the experimenter to compare different nonorthogonal designs in order to select an appropriate layout to examine the contrasts of main importance for the intrablock analysis. Alternative designs are considered to exemplify the problems faced by an investigator, and appropriate solutions are proposed to ensure that experimental material is used efficiently. Recovery of information provides an additional dimension to the problem, and the comparison of contrasts in simple unbalanced mixed models is also addressed.

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