Abstract #301696

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JSM 2003 Abstract #301696
Activity Number: 96
Type: Contributed
Date/Time: Monday, August 4, 2003 : 8:30 AM to 10:20 AM
Sponsor: Biometrics Section
Abstract - #301696
Title: Modeling Cognitive Change over Time in Patients with Alzheimer's Disease
Author(s): Chandrasekhar V. Damaraju*+ and Kaushik Patra
Companies: Johnson & Johnson Pharmaceutical Research and Development, LLC and Johnson & Johnson Pharmaceutical Research and Development, LLC
Address: 1125 Trenton-Harbortown Rd., E12812, Titusville, NJ, 08560-1504,
Keywords: Alzheimer's Disease (AD) ; cognitive subscale ; growth curve model ; nonlinear ; changepoint model ; rate of change
Abstract:

Changepoint models are well suited to understand the rate of change in response to treatment and/or the changing status of the disease itself over time. In the context of Alzheimer's disease clinical trials, we propose a model to describe the change in cognitive (subscale) score obtained from long-term follow-up data where the change in the cognitive status of a patient over time is not linear. We also attempt to predict the benefit accruing a patient with continued therapy relative to an untreated patient.

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