Abstract #301669

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JSM 2003 Abstract #301669
Activity Number: 423
Type: Contributed
Date/Time: Wednesday, August 6, 2003 : 2:00 PM to 3:50 PM
Sponsor: Biometrics Section
Abstract - #301669
Title: An Improved Model-free Test of Synergy in Drug Combinations
Author(s): Colleen Kelly*+
Companies: San Diego State University
Address: 5500 Campanile Dr., San Diego, CA, 92182-0001,
Keywords: synergy ; drug interactions ; dose response curves ; dose response surface ; additivity
Abstract:

In 1994, Laska et al. proposed a new method of detecting synergy in two drug combinations that required no assumptions about the underlying dose-response curves of the drugs. This method consists of comparing the response to a single combination dose to that at two marginal doses (drug A given alone and drug B given alone). The combination dose is declared to be synergistic if the response to the combination dose is demonstrated to be significantly larger than that at the two marginal doses with the Min test. Laska et al. noted that the power of this method is highly dependent on the accuracy with which the potency ratio of the two drugs is estimated. Additionally, the Min test has been shown to be very conservative, and non-monotonic alternative tests have been proposed. We suggest a revision to Laska et al.'s model-free test that has greater power.

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