Abstract #301327

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JSM 2003 Abstract #301327
Activity Number: 219
Type: Contributed
Date/Time: Tuesday, August 5, 2003 : 9:00 AM to 10:50 AM
Sponsor: Biopharmaceutical Section
Abstract - #301327
Title: Effect of N-Acetylcysteine on the Formation of Dense Cells and the Quality of Life for Patients with Sickle Cell Disease
Author(s): Madhuri Mulekar*+ and James Dixon and Betty Pace
Companies: University of South Alabama and University of South Alabama and
Address: Dept. of Math & Stat., Mobile, AL, 36688-0002,
Keywords: repeated measures ; SF-36 ; categorical data analysis ; Sickle Cell Disease
Abstract:

Sickle cell disease is a genetic disorder. It leads to vaso-occulsive episodes among the patients and affects their quality of life. A phase II double blind clinical trial was conducted to study effect of different doses of N-acetylcycteine (NAC) on blood cells. In this study, SF-36 was used to explore existence of a possible association between different indicators of quality of life for patients with Sickle-cell Anemia and various levels of treatment with NAC. Patients were randomly assigned to different groups, each group receiving different dose. Data were analyzed using Minitab and JMP. NAC was shown to inhibit dense cell and ISC formation in sickle red and restore glutathione levels towards normal. Patients receiving NAC treatment rated their health to be better during the treatment period compared to those receiving placebo. They consistently reported lower average interference in social life due to pain or physical and emotional problems.

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