Abstract #301161

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JSM 2003 Abstract #301161
Activity Number: 60
Type: Contributed
Date/Time: Sunday, August 3, 2003 : 4:00 PM to 5:50 PM
Sponsor: Biometrics Section
Abstract - #301161
Title: Case-control Studies with Longitudinal Covariates
Author(s): Honghong Zhou*+ and Xihong Lin and Bin Nan
Companies: University of Michigan and University of Michigan and University of Michigan
Address: 1678 Weatherstone Dr., Ann Arbor, MI, 48108-3325,
Keywords: case-control studies ; longitudinal covariates ; linear mixed model
Abstract:

We consider case-control studies with longitudinal covariates. In a case-control study, subjects are recruited according to their case and control status. In the presence of longitudinal covariates, the covariates are collected longitudinally but retrospectively. We assume the longitudinal covariates follow a linear mixed model and the primary binary outcome relates to longitudinal covariates through latent subject specific random intercepts and slopes. We show that the data can be analyzed prospectively. We conduct some simulations to evaluate the performance of several estimation procedures such as two-stage, regression calibration and maximum likelihood.

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