Abstract #300867

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JSM 2003 Abstract #300867
Activity Number: 28
Type: Contributed
Date/Time: Sunday, August 3, 2003 : 2:00 PM to 3:50 PM
Sponsor: Biometrics Section
Abstract - #300867
Title: Efficient Precision Mapping of Quantitative Trait Loci with Dense Marker Maps
Author(s): Natascha Vukasinovic*+ and Fengxing Du
Companies: Monsanto Company and Monsanto Animal AG
Address: 700 Chesterfield Pkwy. West, Chesterfield, MO, 63017-1732,
Keywords: quantitative trait loci ; linkage analysis ; linkage disequilibrium ; marker map
Abstract:

Advances in DNA technology result in increased density of polymorphic marker maps in all species. Dense marker maps are advantageous because they enable more precise mapping of quantitative trait loci (QTL). QTL mapping is usually performed using linkage analysis, where inheritance of a chromosomal region through a couple of generations is traced using markers. Linkage analysis is robust and efficient, but it usually places a QTL within a relatively wide region, even with a very dense marker map, because closely linked markers are likely to co-segregate within a small number of generations. Methods for linkage disequilibrium mapping use all recombinations that contribute to the linkage disequilibrium between markers and the QTL, thus increasing the precision of QTL mapping. However, QTL inference may be difficult, because the linkage disequilibrium can be caused by evolutionary forces such as selection or migration. In order to quantify advantages and disadvantages of both methods in various mapping populations, we compare the efficiency of linkage analysis and linkage disequilibrium mapping in simulated populations with dense marker maps and different pedigree structures.

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