Abstract #300826

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JSM 2003 Abstract #300826
Activity Number: 249
Type: Contributed
Date/Time: Tuesday, August 5, 2003 : 10:30 AM to 12:20 PM
Sponsor: Biometrics Section
Abstract - #300826
Title: Nonparametric Bayesian Survival Analysis Using Mixtures of Weibull Distributions
Author(s): Athanasios Kottas*+
Companies: University of California, Santa Cruz
Address: Dept. of Applied Math & Statistics, Santa Cruz, CA, 95064,
Keywords: censored observations ; Dirichlet process mixture models ; hazard function ; median survival time ; survival function
Abstract:

Bayesian nonparametric methods have been applied to survival analysis problems since the emergence of the area of Bayesian nonparametrics. However, the use of the flexible class of Dirichlet process mixture models has been rather limited in this context.This is, arguably, to a large extent, due to the standard way of fitting such models that precludes full posterior inference for many functionals of interest in survival analysis applications. To overcome this difficulty, we provide a computational approach to obtain the posterior distribution of general functionals of a Dirichlet process mixture. We model the survival distribution employing a flexible Dirichlet process mixture, with a Weibull kernel, that yields rich inference for several important functionals. In the process, a method for hazard function estimation emerges. The details for simulation-based model fitting, in the presence of censoring, are provided. A method for prior specification is discussed. We illustrate the modeling approach with simulated and real data.


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