Abstract #300799

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JSM 2003 Abstract #300799
Activity Number: 273
Type: Invited
Date/Time: Tuesday, August 5, 2003 : 2:00 PM to 3:50 PM
Sponsor: Biometrics Section
Abstract - #300799
Title: Analysis of Transcription Factor Enrichment Data Generated from Affymetrix Human Genome Tiling Arrays
Author(s): Stefan Bekiranov*+
Companies: Affymetrix Inc.
Address: 6550 Vallejo St., Emeryville, CA, 94608,
Keywords: transcription factor ; consensus sites ; genetic networks ; Wilcoxon rank sum test
Abstract:

Gene expression is controlled by DNA binding proteins whose chromosomal locations are experimentally and computationally difficult to identify. We demonstrate that application of Wilcoxon Rank Sum tests to data generated from hybridizing DNA, which is enriched in regions where these proteins bind, to Affymetrix human genome tiling arrays identifies real binding sites. The array detected regions reveal statistically significant enrichment of consensus sequences and proximity to 5' exons and CpG islands. We discuss the implications this approach has on characterization of gene regulatory networks in human cells.

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Revised March 2003