Abstract #300790

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JSM 2003 Abstract #300790
Activity Number: 300
Type: Contributed
Date/Time: Tuesday, August 5, 2003 : 2:00 PM to 3:50 PM
Sponsor: Biometrics Section
Abstract - #300790
Title: Summarizing FLARE Assay Images in Colon Carcinogenesis
Author(s): Malgorzata Leyk Williams*+ and Raymond J. Carroll and Danh V. Nguyen
Companies: Texas A&M University and Texas A&M University and
Address: Department of Statistics, College Station, TX, 77843-3143,
Keywords: colon carcinogenesis ; FLARE assay ; electrophoresis ; image analysis ; corn oil ; fish oil
Abstract:

Intestinal tract cancer is one of the more common cancers in the United States. While in some individuals there is a genetic component that causes the cancer, the rate of cancer is believed to be affected by diet.This paper has a two-fold purpose. First, it will examine the differences in fish and oil diets and their effect on the rate of colon and duodenum cancer using a FLARE assay. Second, it will consider alternative ways of analyzing FLARE assay data. Since cancer may take a long time before it is detected, the amount of oxidative damage was used as a cancer biomarker in the study. The FLARE assay measures the amount of oxidative damage in a nucleus of a cell. The data are hierarchical, with 100 or more images available for most of the animals. Previous analysis has concentrated on simple summary statistics and found no significant diet effect. By considering the shape of FLARE intensity histograms, we showed strong diet differences, and we isolated where the major differences are in the intensity histograms.

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