Abstract #300719

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JSM 2003 Abstract #300719
Activity Number: 192
Type: Invited
Date/Time: Tuesday, August 5, 2003 : 8:30 AM to 10:20 AM
Sponsor: IMS
Abstract - #300719
Title: Case-sibling Gene-Association Studies for Diseases with Variable Age at Onset
Author(s): Peter Kraft*+
Companies: University of California, Los Angeles
Address: 915 1/2 S New Hampshire, Los Angeles, CA, 90006-6007,
Keywords: allelic association ; survival analysis ; family studies
Abstract:

Many complex diseases have variable age at onset. However, standard analytic methods for family-based studies--designed to adjust for possible confounding by population stratification--are based on a binary disease model and consequently can be inefficient or biased. This talk reviews methods for analyzing censored age-at-onset data from family studies, including a novel "retrospective likelihood," which can both test for allelic association and estimate allelic relative hazards. The retrospective likelihood can be more efficient and accurate than standard methods but requires a reasonable external estimate of the baseline hazard.

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