Abstract #300715

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JSM 2003 Abstract #300715
Activity Number: 451
Type: Contributed
Date/Time: Thursday, August 7, 2003 : 8:30 AM to 10:20 AM
Sponsor: Biometrics Section
Abstract - #300715
Title: Application of Reliability Coefficients in cDNA Microarray Data Analysis
Author(s): Wenqing He*+
Companies: Samuel Lunenfeld Research Institute
Address: Mt. Sinai Hospital, Toronto, ON, M5G 1X5, Canada
Keywords: microarray ; reliability coefficients ; normalization ; gene selection
Abstract:

Gene expression microarray is an innovative technology with enormous promise to help molecular biologists and clinical investigators explore and understand gene functions. It can study simultaneous changes in expression across thousands of genes. The microarray experiment is a complicated procedure with numerous sources of variations. Many normalization procedures have been proposed to eliminate those systematic errors, but which ones are good and which ones are necessary is still not entirely clear. We introduce a criterion to assess the effectiveness of normalization procedures in eliminating systematic variations, and show how it works for assessing normalization procedures. In addition, only selected genes will be included in the final analysis. The existing methods for gene selection are kind of arbitrary. We propose that gene-specific reliability coefficients can serve as a criterion for gene selection. The approach was applied to a study of soft tissue sarcoma tumor specimens analyzed using 19k cDNA microarrays to explore gene expression in both lower-grade and high-grade tumors.

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