Abstract #300682

This is the preliminary program for the 2003 Joint Statistical Meetings in San Francisco, California. Currently included in this program is the "technical" program, schedule of invited, topic contributed, regular contributed and poster sessions; Continuing Education courses (August 2-5, 2003); and Committee and Business Meetings. This on-line program will be updated frequently to reflect the most current revisions.

To View the Program:
You may choose to view all activities of the program or just parts of it at any one time. All activities are arranged by date and time.

The views expressed here are those of the individual authors
and not necessarily those of the ASA or its board, officers, or staff.

Back to main JSM 2003 Program page
JSM 2003 Abstract #300682
Activity Number: 204
Type: Contributed
Date/Time: Tuesday, August 5, 2003 : 8:30 AM to 10:20 AM
Sponsor: Section on Bayesian Stat. Sciences
Abstract - #300682
Title: Robust Bayesian Randomized Clinical Trials
Author(s): J Andrés Christen*+ and Peter Mueller and J. Kyle Wathen
Companies: CIMAT and University of Texas M.D. Anderson Cancer Center and University of Texas M.D. Anderson Cancer Center
Address: AP 402, Guanajuato, GTO, , 36000, Mexico
Keywords: clinical trials ; backward induction ; utility functions ; robustness
Abstract:

We investigate a novel phase II randomized clinical trial design using sequential Bayesian inference. The benefits and drawbacks of obtaining any response by applying a particular treatment, for each patient in the trial, are taken into consideration. Robustness is introduced by considering several utility functions representing various, perhaps conflicting, perspectives commonly present in any clinical trial (patients' perspectives, physician' perspectives, etc.). Randomization is introduced among the "nondominated" set of treatments, allowing for interim removal of treatments and early stopping. A case study is developed and the operating characteristics of the trial are investigated using simulation.

  • The address information is for the authors that have a + after their name.
  • Authors who are presenting talks have a * after their name.

Back to the full JSM 2003 program

JSM 2003 For information, contact meetings@amstat.org or phone (703) 684-1221. If you have questions about the Continuing Education program, please contact the Education Department.
Revised March 2003