Abstract #300612

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JSM 2003 Abstract #300612
Activity Number: 28
Type: Contributed
Date/Time: Sunday, August 3, 2003 : 2:00 PM to 3:50 PM
Sponsor: Biometrics Section
Abstract - #300612
Title: A Maximum Likelihood-Based Interval Mapping Model for Autopolyploids
Author(s): Dachuang Cao*+ and Bruce A. Craig and Rebecca W. Doerge
Companies: Purdue University and Purdue University and Purdue University
Address: Dept. of Statistics, West Lafayette, IN, 47907,
Keywords: QTL mapping ; interval mapping ; autopolyploids
Abstract:

While extensive progress has been made in quantitative trait locus (QTL) mapping in diploid species, the progress for QTL mapping in polyploids has been limited due to the complex nature of the genetic architecture in polyploids. To date QTL mapping in polyploids based on maximum likelihood methods has focused mainly on tetraploids with dominant markers and/or codominant markers. We have extended current work to include model selection to locate the QTL, estimate the marker dosages, QTL dosages, and the trait effect simultaneously for any even ploidy level with multiple dose markers and trait information. Our approach selects the most likely chromosomal configuration (model) by interval mapping to represent the parental configuration, which produced the observed progeny. A Bayesian approach is applied for the purpose of exploring the model space, and the EM algorithm is then employed to estimate the likelihood function and model parameters. Although it is presented via a pseudodoubled backcross experiments, our approach can be readily extended to other breeding systems.

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