JSM 2003 Online Program

Abstract #300587

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Activity Number:	428
Type:	Invited
Date/Time:	Thursday, August 7, 2003 : 8:30 AM to 10:20 AM
Sponsor:	WNAR
Abstract - #300587
Title:	Exploratory Detection of Differential Gene Expression
Author(s):	John Storey*+
Companies:	University of California, Berkeley
Address:	367 Evans Hall, #3860, Berkeley, CA, 94720-3860,
Keywords:	differentially expressed genes ; DNA microarrays ; false discovery rates ; gene chips ; p values ; q values
Abstract:	We present a statistical method for detecting differentially expressed genes in DNA microarray experiments that draws on ideas from hypothesis testing, machine learning, and false discovery rates. The final product of this methodology is a listing of genes in order of evidence for differential gene expression, as well as a gene-wise measure of significance called the q value. We apply this methodology to a well-known dataset and show that it is empirically more powerful than other popular methods. Connections to previously proposed frequentist and Bayesian methods are also described.

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