Abstract #300545

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JSM 2003 Abstract #300545
Activity Number: 458
Type: Invited
Date/Time: Thursday, August 7, 2003 : 10:30 AM to 12:20 PM
Sponsor: Biometrics Section
Abstract - #300545
Title: Family-Based Tests of Association/Linkage between General Phenotypes and Haplotypes
Author(s): Nan Laird*+ and Stephen Lake and Xin Xu and Steve Horvath
Companies: Harvard School of Public Health and Harvard University and Harvard School of Public Health and University of California, Los Angeles
Address: 655 Huntington Ave., Boston, MA, 02115-6009,
Keywords: statistical genetics ; association tests ; haplotypes ; family-based samples
Abstract:

We provide a strategy for testing association/linkage between disease phenotypes and haplotypes that utilizes family-based controls. The method extends the approach for testing described in Rabinowitz and Laird (2000) to handle multiple tightly linked markers. It is robust to population admixture, yet efficient in the sense that it utilizes data from families where phase cannot be completely resolved in all individuals by using weights. The weights are determined from the probability of phase given the observed data, and are estimated from the sample. However, the method remains robust to population stratification and population admixture. The method can handle any type of phenotype, including multiple phenotypes and missing parents, marker data, and/or phase, and provides both bi-allelic and multi-allelic tests. An application to asthma genetics will be presented. The extension has been implemented in our freely available software FBAT.

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