Abstract #300335

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JSM 2003 Abstract #300335
Activity Number: 106
Type: Invited
Date/Time: Monday, August 4, 2003 : 10:30 AM to 12:20 PM
Sponsor: IMS
Abstract - #300335
Title: Incorporating Spatial Information into False Discovery Rate Procedures
Author(s): Jonathan E. Taylor*+
Companies: Stanford University
Address: 390 Serra Mall, Stanford, CA, 94305,
Keywords: multiple comparisons ; FDR ; spatial dependence
Abstract:

False Discovery Rate (FDR) controlling procedures are multiple testing hypothesis procedures that seek to control the proportion of false positives rejected, whereas more traditional procedures seek to control the so-called Family Wise Error Rate, the probability of any false positives occuring. The FDR controlling procedures give sensible answers when the tests are independent, or when the number of tests is very large, as in microarray or neuroimaging data. One weakness of the FDR in problems with spatial structure, such as neuroimaging, is the fact that, for large samples, the FDR is strictly a marginal measure of error and no use is made of the spatial structure of the data. We will review FDR controlling procedures and an alternative way of looking at the procedures. We will suggest ways of incorporating spatial dependence into the FDR procedures, while retaining the simple interpretation of the FDR.

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