Abstract #300294

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JSM 2003 Abstract #300294
Activity Number: 428
Type: Invited
Date/Time: Thursday, August 7, 2003 : 8:30 AM to 10:20 AM
Sponsor: WNAR
Abstract - #300294
Title: Pooling Designs for Microarray Studies
Author(s): Christiana Kendziorski*+
Companies: University of Wisconsin, Madison
Address: Dept. of Biostatistics and Medical Info, Madison, WI, 53726-0001,
Keywords: microarrays ; experimental design ; pooling samples
Abstract:

Statistical calculations have shown that, under certain conditions, pooling messenger RNA (mRNA) samples across subjects can reduce the effect of biological variability and in so doing reduce the number of arrays required in a microarray experiment (Kendziorski, et al. 2003). A main simplifying assumption made in these calculations is that variability across an array is not gene-dependent. This, of course, is not the case. I will present an extension of these calculations to account for gene-specific variance components as well as alternative estimators of expression. In addition, I will discuss how mRNA pooling affects both estimation of expression and identification of differentially expressed genes. Assumptions and results are checked using data from a cDNA microarray experiment.

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