Abstract #300249

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JSM 2003 Abstract #300249
Activity Number: 378
Type: Contributed
Date/Time: Wednesday, August 6, 2003 : 12:00 PM to 1:50 PM
Sponsor: General Methodology
Abstract - #300249
Title: Semiparametric Analysis of Mean Response Model Accounting for Latent Lag and Saturation Times
Author(s): Jingrong Yang*+
Companies: University of California, Berkeley
Address: 33 Union Square #215, Union City, CA, 94587,
Keywords: lag time ; saturation time ; semiparametric
Abstract:

Existing models for repeated measurements usually assumes that the agent of interest produces the full effect on a subject upon exposure and that the effective period is persistent. However, in reality, there is usually a lag time and the period of impact is also often limited. In this talk, we propose a class of multiplicative regression models for the repeated measurements accounting for the existence of subject-specific response lag and saturation times. The least-squares type of estimators for parameters are introduced to accommodate the repeated measurements at irregular observation time points. The results of simulations and real data analysis are presented as well.

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