Abstract #300176

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JSM 2003 Abstract #300176
Activity Number: 102
Type: Invited
Date/Time: Monday, August 4, 2003 : 10:30 AM to 12:20 PM
Sponsor: Section on Statistics in Epidemiology
Abstract - #300176
Title: Issues in the Analysis of Data on Mother-to-Child Transmission of HIV-1
Author(s): Barbra Richardson*+
Companies: University of Washington
Address: Harborview Medical Center, Box 359909, Seattle, WA, 98104-2499,
Keywords: HIV-1 ; infectious diseases ; survival analysis ; interval censoring ; prospective studies ; cohort studies
Abstract:

Mother-to-child transmission of HIV-1 can occur in-utero, during delivery of the infant, or through breastfeeding. Data resulting from prospective studies of mother to child transmission of HIV-1 present unique analysis challenges. The challenges are especially problematic in studies done in breastfeeding populations, since, in this setting, infant infections occurring early in life could be attributed to more than one mode of transmission. Analysis challenges include the difficulty in defining the timing of infection, lack of sensitivity and/or specificity of the diagnostic test for outcome, interval censored outcome data, and informative censoring induced by mortality of infants with unknown HIV-1 infection status. I will provide an overview of issues in the analysis of data from HIV-1 mother-to-child transmission studies, along with brief descriptions and examples of various analytic approaches from the recent literature that address some of these challenges.

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