Abstract #300074

This is the preliminary program for the 2003 Joint Statistical Meetings in San Francisco, California. Currently included in this program is the "technical" program, schedule of invited, topic contributed, regular contributed and poster sessions; Continuing Education courses (August 2-5, 2003); and Committee and Business Meetings. This on-line program will be updated frequently to reflect the most current revisions.

To View the Program:
You may choose to view all activities of the program or just parts of it at any one time. All activities are arranged by date and time.

The views expressed here are those of the individual authors
and not necessarily those of the ASA or its board, officers, or staff.

Back to main JSM 2003 Program page
JSM 2003 Abstract #300074
Activity Number: 227
Type: Invited
Date/Time: Tuesday, August 5, 2003 : 10:30 AM to 12:20 PM
Sponsor: Section on Statistics in Epidemiology
Abstract - #300074
Title: Methodological Issues for Assessing Disease Associations with SNP Haplotypes and Environmental Variables in Case-Control Studies
Author(s): Lue Ping Zhao*+
Companies: Fred Hutchinson Cancer Research Center
Address: 1100 Fairview Ave. MW 803, Seattle, WA, 98109,
Keywords: haplotype ; case-control ; SNP ; linkage-disequilibrium ; allel ; genetics
Abstract:

The rough draft of the Human Genome Map has been used to identify most of the functional genes in the human genome as well as nucleotide variations in these genes, known as single nucleotide polymorphisms (SNPs). Coupled with advanced biotechnologies, researchers are beginning to genotype thousands of SNPs from biological samples. One of significant applications is the study of SNP associations with complex human diseases, such as cancers or coronary heart diseases using a case-control study design. By gathering environmental risk factors and other lifestyle factors, such a study can be effectively used to study interactions between genes and environmental factors in their associations with disease phenotype. In this talk, we describe an analytic method for assessing the association of the haplotypes along with environmental factors with the disease phenotype, when case-control study design is used. Asymptotic properties of estimations in the method are proved theoretically and tested for finite sample sizes using simulations. Several design issues are considered.

  • The address information is for the authors that have a + after their name.
  • Authors who are presenting talks have a * after their name.

Back to the full JSM 2003 program

JSM 2003 For information, contact meetings@amstat.org or phone (703) 684-1221. If you have questions about the Continuing Education program, please contact the Education Department.
Revised March 2003