JSM 2003 Online Program

Abstract #302383

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Activity Number:	316
Type:	Invited
Date/Time:	Wednesday, August 6, 2003 : 8:30 AM to 10:20 AM
Sponsor:	General Methodology
Abstract - #302383
Title:	Pre-Validation and Inference in Microarrays
Author(s):	Robert J. Tibshirani*+ and Bradley Efron
Companies:	University of Toronto and Stanford University
Address:	Dept. of Preventive Med/Biostats, Toronto, ON, M5S 1A8, Canada
Keywords:
Abstract:	In microarray studies, an important problem is to compare a predictor of disease outcome derived from gene expression levels to standard clinical predictors. Comparing them on the same dataset that was used to derive the microarray predictor can lead to results strongly biased in favor of the microarray predictor. We propose a new technique called "pre-validation" for making a fairer comparison between the two sets of predictors. We study the method analytically and explore its application in a recent study on breast cancer.

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