Abstract #302369

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JSM 2003 Abstract #302369
Activity Number: 354
Type: Topic Contributed
Date/Time: Wednesday, August 6, 2003 : 10:30 AM to 12:20 PM
Sponsor: General Methodology
Abstract - #302369
Title: Exact Inference in Crossover Designs
Author(s): Sam Weerahandi*+ and John J. Peterson
Companies: Bellcore and GlaxoSmithKline
Address: Room 751B, TDS, New York, NY, 10020,
Keywords: generalized p values ; Balaam design ; unequal carryover effects
Abstract:

For many crossover designs there are only asymptotic results available in the literature. We consider one of the simplest designs available for comparing two treatments, namely the Balaam design. This design does not require one to assume that carryover effects from one period to the next are equal or that occasion (period) effect is zero. Even for this simple design, practitioners have to resort to asymptotic methods for making inferences. To overcome the underlying inference problems, we take the generalized approach and obtain p values and confidence intervals that are based on exact probability statements. Some simulation results will also be presented to shoe the superiority of the proposed test over asymptotic test is established.

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