Abstract #302300

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JSM 2003 Abstract #302300
Activity Number: 337
Type: Contributed
Date/Time: Wednesday, August 6, 2003 : 8:30 AM to 10:20 AM
Sponsor: Biopharmaceutical Section
Abstract - #302300
Title: Variance Functions and Test Statistic Adjustments in the Differential Expression Analysis of Microarray Data
Author(s): Michael A. O'Connell*+ and Perry D. Haaland and Jae Kyun Lee and Phillip Stafford
Companies: Waratah Corp and Becton Dickinson Technologies and University of Virginia and Arizona State University
Address: 2505 Meridian Pkwy., Durham, NC, 27713-5246,
Keywords:
Abstract:

We compare several methods in the analysis of differential expression in microarray data. These include (a) the local pooled error method described by Lee and O'Connell (2003) and Jain et al. (2003), (b) the transformation and error-pooling approach described by Durbin and Rocke (2002) and Geller et al. (2002), and (c) a new modified SAM-bootstrap procedure based on the SAM method described by Storey and Tibshirani (2003). The methods are compared using (a) controlled liver and heart datasets from a variety of microarray platforms (Affymetrix, Amersham, Mergen and Agilent), (b) a designed experiment using Clontech data, and (c) simulated data.

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